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Previous studies in mouse models have demonstrated that MC4R deficiencyparticularly when combined with MC3R or LDL-receptor lossexacerbates metabolic disturbances, resulting in marked hypercholesterolemia with elevated LDL and very low-density lipoprotein fractions, as well as triglycerides, thereby fostering a pro-atherogenic lipid profile [94, 95]

10.1007/s00204-017-2036-4 Arch

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Weight loss compounds present a fundamental problem: they typically require much larger doses to be effective than can realistically be delivered through the skin

Platelet membrane biomimetic nanoparticle-targeted delivery of TGF-1 siRNA attenuates renal inflammation and fibrosis