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This is one reason head-to-head binding assays dont always match head-to-head secretion experiments and why researchers occasionally get surprised when GHRP-6 outperforms GHRP-2 in certain model contexts despite lower receptor binding affinity on paper
Janicka A, Szymanska-Pasternak J, Bober J
The D-retro-inverso design was critical to the compound's success
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