It increases the tone of the detrusor urinae muscle , usually producing a contraction sufficiently strong to initiate micturition and empty the bladder It stimulates gastric motility , increases gastric tone, and often restores impaired rhythmic peristalsis Because of the selective action of bethanechol, nicotinic symptoms of cholinergicstimulation are usually absent or minimal bethanechol is not hydrolyzed by cholinesterase enzymes, resulting in a longer duration of action compared to acetylcholine and other enzyme-sensitive choline esters FDA Approved Indications: To promote emptying of the urinary bladder, including: (but rarely used) Postoperative urinary retention (POUR) Postpartum nonobstructive urinary retention Neurogenic atony of the urinary bladder with retention of urine
Selective inhibitors have more specificity and low adverse events compared to non-selective ones
In addition, the benefits of glutathione for skin extend to supporting immunity and maintaining overall cellular health
However, for musculoskeletal and systemic applications, subcutaneous injection delivers the peptide directly into systemic circulation at predictable concentrations
BPC-157 completely eliminated autotomy behavior, suggesting direct effects on neuropathic pain reduction alongside structural nerve repair