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M., Satylganova, A., & Lau, D

Mutations in the histamine N-methyltransferase gene, HNMT, are associated with nonsyndromic autosomal recessive intellectual disability

Ultimately, Compound 13 (DNS-0056) with pyran-methyl-pyridine and fluoro-methoxybenzyl substitutions at positions C-6/C-8 and C-9, respectively, emerged as the most potent derivative and was not a substrate of MDR1 (efflux ratio: 1.0) (Figure 5)