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Additionally, metformin inhibits mitochondrial respiratory chain complex I, which lowers proton leak and ROS generation in hepatocyte mitochondria, thereby reducing hepatocyte apoptosis to treat DILI (99)
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Despite existing preventative, diagnostic, and treatment methods, such as chemotherapy, the number of instances rises year after year
For example, cancer cells exhibit significant metabolic plasticity, switching between glycolysis and OXPHOS via complex metabolic networks mediated by HIF-1 and AMPK
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