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Description

In the oxidative half of the mechanism, Cys63 nucleophilically attacks the nearest sulfide unit in the glutathione disulfide (GSSG) molecule, which creates a mixed disulfide bond (GS-Cys58) and a GS- anion

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Abstract P6-20-07: efficacy and safety of CB-839, a small molecule inhibitor of glutaminase, in combination with paclitaxel in patients with advanced triple negative breast cancer (TNBC): initial findings from a multicenter, open-label phase 2 study

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doi: 10.1042/CS20110006 66 PathakNMPathakVGaultVAMcCleanSIrwinNFlattPR

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Notably, LA supplementation can also alter circadian rhythms

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