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3.1.1 AMPK signaling pathway activators 3.1.1.1 Piericidin analogue S14 (PA-S14) Many natural products can stimulate mitochondrial biogenesis and energetics via AMPK signaling pathway

These hydroxylation reactions also require Fe 2+ as a cofactor, O 2 as a cosubstrate and ascorbic acid (vitamin C) as a reductase, which restore the activity of 2-OGDD enzymes (Fig

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