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Metformin, the cornerstone of T2DM therapy, activates AMP-activated protein kinase (AMPK), which has been shown to normalize SR/ER-mitochondria interactions ( 2+ overload (Wu et al., 2019)
Anti-diabetic therapy and heart failure: recent advances in clinical evidence and molecular mechanism
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These pathways are commonly studied in experimental models to understand how peptide signaling influences adipocyte function and energy metabolism
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