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No one should be taking these medicines without the guidance of a physician or other good providers, says Spencer Nadolsky, DO, the physician-founder of Vineyard.com, which abides by FDA criteria for prescribing GLP-1s, and offers access to registered dietitians and a strength coach
A notable example is the CUR-PPR interaction: while PPR enhances CURs bioavailability by inhibiting CYP3A4 and P-gpcritical enzymes for CUR metabolismvia competitive binding to their active sites, this inhibition prolongs systemic CUR exposure
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Specifically, there was a small-to-moderate decrease in binge eating severity, with effect sizes indicating meaningful improvements across multiple studies
Steyger 2021a
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