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10.1016/S1474-4422(08)70116-9 Lancet Neurol
These polymers are formed through enzyme-catalyzed chain-growth polymerization processes of activated monomers (Sun et al., 2022)
Confocal and electron microscopy showed that CAR-SIV colocalized with insulin, ZnT8, and PC1/3 within insulin granules
The tradeoff: nearly all data comes from rodent studies
Patients who report constipation starting in weeks 1-4 fall into two groups by week 6: Group 1 (adapters, ~65% of those with early constipation): Bowel movement frequency has stabilized or started improving by week 6
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