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More recently, activating mutations in CYSLTR2 and PLCB4 which encode proteins that function upstream and downstream of GNAQ and GNA11 in the G alpha Q pathway, respectively (Fig
Referring to the docking modes from earlier studies, the highest-scoring binding modes in these conformations were selected (Fig
Statistical significance was calculated by two-way ANOVA followed by multiple comparisons in a-c, f , and g and unpaired two-sided t-test in e
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