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During the phase 2 trials, researchers monitored injection-site tolerability closely to ensure that local reactions did not undermine patient adherence or signal broader immune-related problems

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The study was done on taekwondo athletes using 20g of creatine plus 0.5g/kg of sodium bicarbonate.[ref] Guanidinoacetic acid (GAA): Creatine + GAA was shown to be a little bit better at increasing creatine levels in skeletal muscle and gray matter in the brain.[ref] However, some studies point to GAA increasing oxidative stress in the brain.[ref] Doses for cognitive function: The optimal dose of creatine likely depends on someones underlying brain health

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