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They are for type 2 diabetes and weight loss in people who make insulin

Common gastrointestinal effects are the most frequently reported adverse reactions, with studies reporting variable rates of digestive symptoms: Diarrhoea and loose stools Abdominal cramping and discomfort Constipation (less common) Nausea and bloating These effects are typically dose-dependent and may improve with gradual dose escalation or taking berberine with meals

doi: 10.1038/s41586-018-0849-9 6 YustaBBaggioLLKoehlerJHollandDCaoXPinnellLJet al

They can also interfere with prescribed medicines or cause health issues, such as skin burns or an elevated heart rate