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It also modulates the activity of matrix metalloproteinases (MMPs) and their inhibitors, supporting balanced collagen remodeling rather than excessive breakdown or fibrosis
Molecules (2023)
In wound models, this accelerates re-epithelialization
Phase 2 trial (NEJM, 2023) The landmark Phase 2 trial, published in the New England Journal of Medicine, randomized 338 adults with obesity to receive weekly subcutaneous retatrutide at doses of 1 mg, 4 mg, 8 mg, or 12 mg, or placebo, for 48 weeks
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