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JACC Basic Transl Sci (2018) 3:50317
Lack of baseline measurements for liver steatosis and fibrosis before the initiation of the EDICT study, as well as the small number of patients enrolled were the main limitations of this trial
For instance, H7 of GLP-1 forms hydrogen and hydrophobic interactions with TM3 and TM5 residues like Y 241 , I 309 , R 310 , and I 313 , whereas A8 forms hydrophobic interactions with L 384 and L 388 of TM7
It is dependent on stimulus-secretion coupling, whereby glucose catabolism within pancreatic -cells generates the primary signal for secretion
doi: 10.1097/qad.0000000000002897
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