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The model of CTR: rAmy (CT-like, PDB: 7TYI) was used as the initial template for the CTR:Cagri/CagriBB complex in the CT-like conformation by replacement of the peptide
According to one study, only cells that had lost MDM2 gene functionality underwent senescence [86]
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These alternative weight-loss interventions may not be equally available or affordable to people with obesity in routine clinical practice, but might be adopted more by trial participants if they are made available as part of the trial
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