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Forty L, Smith D, Jones L, Jones I, Caesar S, Cooper C, et al
One small observational study of women with PCOS who continued metformin after semaglutide withdrawal found roughly one-third of the weight regained at two years rather than two-thirds, with most participants still below their starting weight
GLP-1 agonists do not typically alter thyroid hormone levels in patients with normal thyroid function, though TSH may decrease with weight loss
The peptide reaches peak plasma concentrations within 30 minutes and distributes to various tissues including liver, kidney, gastrointestinal tract, and injured tissues
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