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Glucose-6-phosphate dehydrogenase is found in all cells and is responsible for the first reaction of the pentose phosphate pathway in which glucose-6-phosphate is oxidized to 6-phosphogluconolactone with concomitant production of NADPH

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While it activates the GLP-1 receptor, Zepbound also targets the GIP (glucose-dependent insulinotropic polypeptide) receptor, making it a dual receptor agonist

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