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Key safety caveat MK-677 increases appetite substantially (its mechanism overlaps with ghrelin, the hunger hormone), causes water retention, and raises fasting glucose in multiple trials
10.1038/mp.2016.19 274 SuriS.ChiesaS
C., Tobe, R
These medications work by mimicking the action of endogenous GLP-1, a gut hormone that regulates appetite and glucose metabolism
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