This was followed by Victoza and later Saxenda, which marked an important shift, extending GLP-1 therapy from type 2 diabetes into obesity treatment
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Two weeks of exenatide treatment twice daily, 1 h before morning and evening meals, significantly reduces plasma TG following these meals (50% carbohydrate, 20% protein, and 30% fat) compared to placebo but TG levels rise to similar levels as placebo following the midday meal, where no changes in post-prandial FFA concentrations are observed (Schwartz et al., 2008)
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The median time from breast cancer diagnosis to GLP-1 RA initiation was 4.3 years (range, 4.4 to 29.5), and the median duration of GLP-1 RA use was 20 months (range, 6-111 months)