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Accessed July 15, 2025
Even if the main folate receptors are blocked by antibodies, leucovorin can enter the central nervous system through the reduced folate carrier (RFC) , essentially bypassing the roadblock at the FR [4]
Any severe or persistent symptoms should be discussed with the prescribing clinician before continuing
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Strikingly, in a large cross-sectional study ( n = 5725 females and n = 1061 males) menstruation was found as the main trigger factor for migraine episodes in female patients (78% of women) 69 , while postmenopausal women appear to have more similar migraine triggers to male migraine patients than fertile female patients concerning hormonal levels 69
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