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373 These mechanistic insights are now being translated into rationally designed combination regimens in clinical trials, marking a significant shift toward biology-driven therapeutic strategies (Table 3)

Signs of Infection (Cellulitis or Abscess) Progressive worsening after 24-48 hours instead of improvement Spreading redness beyond 5 cm that continues enlarging Marked warmth, throbbing pain, or pain that is severe and out of proportion Purulent drainage (pus), central necrotic/black area, or obvious abscess Fever, chills, malaise, or systemic symptoms Red streaking running up limb toward lymph nodes These require urgent medical evaluation for potential antibiotics, drainage, or both

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Compounded formulations vary in their excipient composition

Razavi MS, Fathi M, Vahednia E, Ardani AR, Honari S, Akbarzadeh F, et al