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Therefore, in line with the current definition of TDP-43 pathology, this mouse model has been considered one of the most reliable models for TDP-43 pathology, especially in the cortex 16,19,39,40,41,42,43

The characteristic loss of Purkinje cells in the brains of people with autism is consistent with depletion of brain glutathione due to excess acetaminophen usage, which leads to premature brain Purkinje cell death

It acts as a powerful antioxidant, neutralising free radicals and protecting cells from oxidative damage

Intracellular reactive oxygen species production may cause cellular damage ( Reference Streck, Vieira and Wannmacher 9 ) and disorders of the antioxidant defence system ( Reference Blundell, Jones and Rose 12 ) , demonstrating a mechanistic connection between hyperhomocysteinaemia, oxidative stress and disease