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34 Fat volume depletion in BS-MWL results from anatomical changes that restrict calorie intake and reduce nutrient absorption and through hormonal shifts and alterations in the gut microbiome that affect appetite, metabolism, and energy expenditure rather than adipocyte cell count depletion
However, preliminary data suggests that tirzepatide and retatrutide may offer more substantial weight loss than semaglutide, but this needs further confirmation through larger-scale, long-term studies
Individuals carrying specific FTO or MC4R variants may experience sharper metabolic shifts that can trigger temporary anxiety as their bodies adapt to improved glucose control and appetite suppression
While cardiovascular death alone didn't reach statistical significance (middle-left panel), consistent directional benefits appeared across heart failure outcomes and all-cause mortality, suggesting broad cardiovascular protection
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