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Enhanced insulin signaling following weight loss has been associated with decreased circulating levels of pro-inflammatory cytokines, including IL-6, TNF-, and C-reactive protein, as well as improvements in endothelial and adipose tissue function ( In inflammatory arthritis, including PsA, improved insulin sensitivity has been independently associated with reduced disease activity and inflammatory burden, even after adjustment for changes in BMI ( Consistent with this concept, GLP-1RAs have been shown to directly modulate immune responses by reducing the secretion of key pro-inflammatory cytokines such as IL-6 and TNF-, which are central drivers of inflammation in both PsO and PsA ( 3.4 Early PsA and future research directions Despite the promising metabolic and immunomodulatory effects observed in PsO, the role of GLP-1RAs in PsA, particularly in its early stages, remains largely unexplored

Reconstitute with bacteriostatic water by adding the water slowly down the inside wall of the vial and gently swirling (not shaking, never vortexing) until the cake fully dissolves

Reconstitution and Storage Both peptides come as lyophilized (freeze-dried) powder that must be reconstituted with bacteriostatic water before injection

Store reconstituted material at 20C in single-use aliquots and avoid repeated freeze-thaw cycles

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