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For example, controlled trials evaluating GLP-1 RAs in major neurocognitive disorders (early Alzheimer disease, Parkinsons disease) have been mixed wherein the primary outcome has been reducing cognitive deterioration and motoric symptom intensification, respectively

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6 The practical takeaway for you: correcting a genuine selenium shortfall is worth doing, but piling extra selenium on top of an adequate intake isn't supported, and, as the next sections explain, it carries real risk

10.1111/j.1471-4159.2009.06379.x J