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GLP-1 medications produce meaningful overall weight loss by reducing appetite, slowing gastric emptying, and driving a caloric deficit
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corroborated by Oostdyk 2024) and downregulates surface GLP-1R within 12 hours at physiological albumin (Hinds 2024), so the sustained signal held against that fade, set by dose, is what carries the effect
gasseri BNR17, L
And so these...now with higher resolution MRI, people are able to show these changes and it's pretty cool
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