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However, tirzepatides dual GIP/GLP-1 agonism involves complex central and peripheral signaling, and while its effects are established, the precise downstream pathways contributing to its neuroprotective actions are still an active area of investigation
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Exp Ther Med 15:50775083 Mieczkowska A, Millar P, Chappard D, Gault VA, Mabilleau G (2020) Dapagliflozin and liraglutide therapies rapidly enhanced bone material properties and matrix biomechanics at bone formation site in a type 2 diabetic mouse model
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Beyond FDA indications, several clinical criteria should be evaluated when considering tirzepatide initiation
