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2023 May 1 [cited 2025 Sep 5];11(5):1362

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Early diagnosis of left ventricular diastolic dysfunction in diabetic patients: a possible role for natriuretic peptides

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In obese mouse models: Animals treated with 5-Amino-1MQ lost significant fat mass compared to controls Effects were most pronounced in visceral adipose tissue the metabolically dangerous fat around organs No cardiovascular toxicity or significant off-target effects were observed at research doses Body weight decreased without appetite changes, suggesting the mechanism was purely metabolic Human data is limited this is still a research compound

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Paradoxically, the very condition tirzepatide treats is itself a major risk factor for gallstones

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