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Hypoxic repression of endothelial nitric-oxide synthase transcription is coupled with eviction of promoter histones

Smoking and Nicotine Dependence NCT05530577: Effects of Semaglutide on Nicotine Intake and Smoking Lapse Status: Completed (Results not Reported) UNC trial investigating the effects of an approved GLP-1 receptor agonist on nicotine intake and reinstatement in humans

Avoid High-Fat and Greasy Foods Heavy meals may remain in the stomach longer while taking semaglutide, making nausea, bloating, indigestion, and reflux worse for some patients

Zofran can be added onto this infusion to combat any nausea if applicable

Though semaglutide appeared to reduce drinking habits, the study noted additional clinical studies with more people are necessary to better understand the drugs effects, including testing among heavier drinkers