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Since the comparison group included other GLP-1s, Xu and colleagues noted that the underlying mechanisms may be specific to semaglutide and tirzepatide, which may include their indirect associations with abrupt changes in metabolic parameters. NAION is rare in general, Xu told Healio

The study found a link, albeit rare, between optic nerve eye disease (including NAION) and semaglutide and tirzepatide