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Sulfate ion serves as a replacement for inorganic phosphate once the acylphosphate intermediate is formed inside the active site
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Exp Neurol 263:235243 Gluckman PD, Williams CE (1992) When and why do brain cells die
The potential benefits include reduced joint pain, improved skin conditions, and better management of obesity-related complications common in autoimmune disorders
The aggregation of these peptides into oligomers and their subsequent deposition as extracellular senile plaques is facilitated by interactions with apolipoproteins and proteoglycans, contributing to the synaptic dysfunction and neurodegeneration that define the disease (Arjmand et al., 2024)
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