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-endorphin, the POMC-derived opioid peptide, has the capacity to upregulate melanogenesis and melanin distribution by promoting maturation of melanocytes and arborisation of their dendritic processes, thus increasing the efficacy of the transfer and distribution of melanosomes to neighbouring keratinocytes [23, 29]
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The combination of Ozempic's gastrointestinal side effects with cannabis use could potentially exacerbate nausea or make it difficult to distinguish between medication side effects and cannabis-related symptoms
[43] Mechanism [edit] The mechanism of melatonin biosynthesis initiates with the hydroxylation of L-tryptophan, a process that requires the cofactor tetrahydrobiopterin (THB) to react with oxygen and the active site iron of tryptophan hydroxylase
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