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In adults with type 2 diabetes, treatment with tirzepatide 5 mg, 10 mg and 15 mg once weekly was associated with superior weight reduction from baseline compared with placebo, semaglutide 1 mg weekly, titrated insulin degludec, titrated insulin glargine and titrated insulin lispro as an add-on to insulin glargine
Glucose (0.2g/mL) was injected intraperitoneally according to body weight (100L/10g)
The average follow-up time with participants was 165 days, and slightly over 50% of participants discontinued each medication
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