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Collectively, these findings demonstrate that psychological trauma initiates a cascade of interconnected MGBA disruptions in PTSD, encompassing HPA axis dysregulation, microbial dysbiosis, compromised gut barrier integrity, chronic inflammation and neurotransmitter imbalances across serotonergic, dopaminergic, and GABAergic systems

Conceptualization, Funding acquisition, Supervision, Writing-review & editing Acknowledgments We thank the high-field NMR facility at the Korea Basic Science Institute (KBSI, Ochang) and the GIST Advanced Institute of Instrumental Analysis (GIST, Gwangju) for allowing us to use their NMR spectrometers

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Presented for research literature review only Szkudelski T et al

204,205 Aberrant activation of this pathway is a well-established mechanism of resistance to targeted therapies, chemotherapy, and endocrine therapy