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In addition, polymeric nanovesicles Gem/Sul-NP which simultaneously encapsulate and deliver gemcitabine and the prolyl isomerase Pin1 inhibitor sulfopin, can effectively remodel the immunosuppressive TME and significantly increases the infiltration of CD8 IFN T cells when combined with anti-PD-1 therapy (190)

However, the interesting part of this study mentioned how as the animals aged there was no clear reduction in longevity despite the obesity that developed, but when these animals were placed on a low-fat diet, lifespan increased by 30%

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