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[1] [7] Additionally, because glucagon promotes glycogenolysis and gluconeogenesis, there is a theoretical concern regarding glucose management in people with type 2 diabetes, although the GLP-1 and GIP components appear to counterbalance this effect in practice

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doi: 10.1038/s41598-022-05667-0 287 ValkoM.LeibfritzD.MoncolJ.CroninM

The mitochondrial origin means MOTS-c acts at the cellular energy level in a way no GHRH analog, tissue-repair peptide, or cognitive peptide does

Brunst KJ, Enlow MB, Kannan S, Carroll KN, Coull BA, Wright RJ