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However, in chronic tendinopathy, its efficacy may be compromised due to persistent inflammation, tissue degeneration, fibrosis, and abnormal ECM composition, which can impede IGF-1 diffusion and diminish the responsiveness of tendon cells (Tang et al., 2024)

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Das KS, Balakrishnan V, Mukherjee S, Vasudevan DM (2008) Evaluation of blood oxidative stress-related parameters in alcoholic liver disease and non-alcoholic fatty liver disease