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However, in a randomized phase III double-blind clinical trial, tivantinib did not improve OS time in patients with Met-high advanced HCC treated with sorafenib compared with placebo (Rimassa et al., 2018) (NCT01755767)

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The optimal approach in a given case often depends on the specific tear characteristics (location and extent), the presence of DRUJ instability or other wrist pathologies, and the surgeons skillset and expertise