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Autophagy can be induced by nutrient deprivation, which activates AMPK (a sensor of energy depletion) and inhibits mammalian target of rapamycin (mTOR, an autophagy suppressor), as well as oxidative stress, hypoxia, exercise, drugs (rapamycin, metformin) and hormones (glucagon)
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However, based on anecdotal evidence and limited research, there are a few safety considerations to be aware of
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