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This mechanism was documented in humans in 1984 by Bowers and confirmed in multiple clinical studies (Nass et al., J Clin Endocrinol Metab 2008)

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2.3.3 Extra-endocrine expression of taste receptors Beyond EECs, it is also important to mention that taste receptors may also be present in the brush cells, a subgroup of solitary chemosensory cells found in the nasal cavity and other regions of the gut, especially where food passes from the fundus to the corpus, and digestive process are initiated, where expression of TAS1R1, TAS1R3, and a-gustducin are involved, suggesting a role in amino acid sensing (60, 78, 79)