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Genetic Variants in Phosphatidylethanolamine N-Methyltransferase (PEMT) and Methylenetetrahydrofolate Dehydrogenase (MTHFD1) Influence Biomarkers of Choline Metabolism When Folate Intake Is Restricted. Journal of the American Dietetic Association, vol
Research published in the context of the SURPASS trial program demonstrated that tirzepatide produced dose-dependent HbA1c reductions of 1.24 to 2.58 percent across the studied dose range, and body weight reductions of 5.4 to 11.7 kilograms in patients with type 2 diabetes
This is about the same as tirzepatide's effect, but it's done through different receptor pathways
J., Butler, A
A total of 10 mg in an adult human should be adequate, which is about 2000 times lower than the LD50 calculated for humans
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