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Treatment of HepG2 cells with different concentrations of NFT or DEM for 24 h led to a concentration-dependent increase in Nrf2 and GCLC protein levels, whereas no significant change was observed in the levels of the modifier subunit, GCLM (Fig

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doi: 10.1089/ars.2014.6097 68 XieYKangRKlionskyDJTangD

This timeline covers what the clinical and preclinical evidence shows at each stage, what community reports consistently describe, and the factors that determine whether results land on the faster or slower end of the spectrum