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TRIUMPH-4 (December 2025) TRIUMPH-1 (May 21, 2026) Semaglutide STEP-1 Trial What Nearly Double the Weight Loss Means in Practice For a patient starting at 250 lbs: These numbers come from separate trials with different populations not a direct head-to-head comparison

A simpler surrogate is the acetaminophen (paracetamol) absorption test : because acetaminophen is negligibly absorbed by the stomach but rapidly absorbed by the small intestine, the rise in its plasma concentration tracks the rate of gastric emptying a convenient method often embedded in early-phase metabolic studies

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