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PMID: 8227353 Secondary Connectivity Map / Broad Transcriptomics Gene Expression Modulation (4,048 Genes) Microarray and CMap analysis reveal that GHK-Cu modulates the expression of 4,048 genes in human fibroblast culturesapproximately 6% of the human genomeaffecting pathways for tissue remodeling, antioxidant defense, anti-inflammatory signaling, and stem cell markers

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This epigenetic regulation involves copper-dependent activation of cellular pathways including enhanced DNA repair, increased antioxidant enzyme production, and stimulation of regenerative processes while simultaneously suppressing inflammatory and destructive gene programs