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References: Mutation of the mouse klotho gene leads to a syndrome resembling ageing Kuro-o et al

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While glucose-derived lactate M + 3 is decreased in 560 min, the incorporation of glucose-derived carbons into TCA cycle metabolites was also reduced upon neuronal differentiation as demonstrated by decreased levels of citrate, succinate, and fumarate M + 2 isotopologues throughout the time course (Fig

Glutathione levels may also go down in people who drink large amounts of alcohol or who smoke cigarettes