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The first GLP-1 receptor agonist, exenatide, was approved in 2005 and has since led to multiple formulations including once-weekly injectables and oral semaglutide
These antidiabetic agents increase the glucose-dependent secretion of insulin from functioning beta cells, decrease glucagon release after meals, decrease hepatic glucose production, delayed gastric emptying, suppress the appetite and promotes beta cell proliferation
Patterson CW, Palines PA, Bartow MJ, et al
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