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These selectivity studies documented that the Aib substitution is the critical structural determinant of Ipamorelins selectivity, eliminating hypothalamic CRH co-stimulation while preserving full somatotroph GHS-R1a engagement establishing Ipamorelin as the reference selective GHRP against which the HPA axis co-stimulation profiles of other GHRPs are benchmarked
mechanism of action and metabolic studies Journal of Endocrinology and Metabolism (2013) Safety and tolerability of AOD9604 in humans
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137, 807 (2006) , (8) J.B
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