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In the SURMOUNT-4 randomized withdrawal study, patients who stopped tirzepatide regained significant weight compared to those who continued treatment
As a full ghrelin mimetic, it activates peripheral and central ghrelin receptor populations at once, producing appetite stimulation, elevated fasting glucose, and fluid accumulation in distal extremities as pharmacologically expected consequences rather than rare adverse effects
Administration of insulin or sulfonylureas
G.Rodriguez-RamiroI.Anis-AlaviM
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