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Unlike single- or dual-incretin analogs, this 39-residue peptide was engineered to engage three class B G-protein-coupled receptors within receptor-expressing cell systems: the glucose-dependent insulinotropic polypeptide receptor (GIPR), the glucagon-like peptide-1 receptor (GLP-1R), and the glucagon receptor (GCGR)
Researchers must also remember to initiate DSIP research at the lowest effective dose and adjust it incrementally, staying vigilant for any adverse reactions
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